Disease Pedigree
Understand genetic disease inheritance patterns and check hereditary probabilities in offspring.
When breeding parents with defective genetic disease genes, the probability of inheritance in offspring is as follows.
Autosomal Inherited Disease Pedigree
Important!
For carriers, the degree of disease manifestation varies depending on the inheritance pattern.
- Autosomal Dominant: Disease symptoms appear with just one mutation in a pair of alleles.
- Autosomal Recessive: Disease symptoms appear only when both alleles in a pair have mutations.
Maternal Inherited Disease Pedigree
Important!
Maternal inherited diseases are inherited only through the maternal line according to mitochondrial DNA inheritance patterns.
X Chromosome-Linked Inherited Disease Pedigree
Important!
For carriers, the degree of disease manifestation varies depending on gender.
- Male: When carrying the mutation (XY), disease symptoms appear regardless of dominant/recessive status.
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Female:
X Chromosome Dominant: Disease symptoms appear with just one mutation (XX') in the two X chromosomes.
X Chromosome Recessive: Disease symptoms do not appear with just one mutation (XX') in the two X chromosomes.